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Am J Med Genet (2001) 102(1):1820

In human unselected lymphocytes and LPS-activated monocytes, 1,8-cineole inhibited the production of cytokines such as IL-4, IL-5, IL-1, and TNF- in lymphocytes

While SRC is a known intermediate in c-MET/HGF signalling, we did not observe induction of p-SRC [Y418] or [Y529] as included in the KPSS screens

Of these substrates, cysteine availability is rate-limiting, rendering glutathione synthesis particularly sensitive to dietary protein quality, sulfur amino acid intake, and intracellular redox demand

The functional assays of CYP3A4 further validate this claim: iHLOs exhibited a concentration-dependent inhibition profile following ketoconazole treatment (IC 50 : 0.83 M), comparable to HepaRG cells but distinct from PHHs